Jonathan Wilhoite Blog: Changes In The Diet: Findings Show Microbes Affect Host’s Body

Friday, November 25, 2016

Changes In The Diet: Findings Show Microbes Affect Host’s Body

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Medical Express reports that scientists have theorized about the effect of microbes to the bodies. However, there has been no clear insight as to how it affects the host. The new research about mice shows that the organisms actually interact with the host by sending metabolites.

These act on histones that eventually influence gene transcription. The findings of the research were released on November 23, 2016 in Molecular Cell.

Changes In The Diet Affect Epigenetics Via The Microbiota

In the study, the researchers first compared germ-free mice with those that have active gut microbes and discovered that gut microbiota alter the host’s epigenome in several tissues. Read more…

The Scientist tells us how the diet actually affects the host. The researchers began deciphering the language of the microbiome. They wanted to establish how these organisms communicate with each other.

After eating, all the organisms in our body interact. The numerous bacteria, viruses, and fungi produce metabolites that let our organs prepare for the incoming nutrients. The microbes actually send messages to the digestive tissues and the findings tell us that three short-chain fatty acids acetate, propionate, and butyrate act on histones that impact gene transcription.

How Diet Influences Host-Microbiome Communication in Mice

Gut microbes produce a wide variety of metabolites, from bile acids to vitamins. Through fermentative reactions, gut microbes can also metabolize complex carbohydrates to form short-chain fatty acids, such as butyrate, which has been implicated in cardiovascular disease and diabetes. Read more…

Science Daily gives us an overview about the study. The experiment involved comparing two groups of mice. One group came from a germ free environment and the other was raised under typical lab conditions.

The researchers were able to identify the essential role of the organisms in our guts. They act as the mediator of host gene expression. They do this through epigenome, the chemical information that is responsible for regulating active cells in genes.

Gut’s Microbial Community Shown To Influence Host Gene Expression

Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance. Read more…

Knowing the mechanisms that surround this activity, it gives us awareness about the right kind of diet that favours this good interaction. In other words, this simplifies everything. It enables us to live a healthier life.

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